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Nothapodytes nimmoniana: Untapped Potential

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  1. 1Deparment of Pharmacognosy, Government College of Pharmacy, Amravati, Maharashtra, INDIA.

CORRESPONDENCE

Sharada Laxman Deore

Deparment of Pharmacognosy, Government College of Pharmacy, Amravati, Maharashtra, INDIA.

sharudeore_2@yahoo.com

Received: 11-04-2025; Accepted: 25-08-2025.

Volume 19, Issue 38 · pp. 138-143 · 2025 · DOI: 10.5530/phrev.20250010

ABSTRACT

The tree species Nothapodytes nimmoniana or Nothapodytes foetida or Mappia foetida of family Icacinaceae commonly known as Ghanera or narakya is of research interest among plant scientist as it contains third most demanding anticancer compound camptothecin and 9-Methoxy camptothecin mainly used for treatment of cervical, breast cancer and few lymphomas. Due to extensive overharvesting to meet market demand of camptothecin, it is now red-listed as per IUCN. More than a 20% decline is reported in N. nimmoniana population in the last decade alone. Conservation efforts are underway, including metabolic engineering of plant cells to boost camptothecin production, aiming to reduce pressure on wild populations. This article provides an overview of pharmacognosy, phytochemistry, pharmacology and biotechnology aspects of Nothapodytes nimmonianaJ. Graham.

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    Deore, S. L., Vighne, R. C., & Baviskar, B. A. (2025). Nothapodytes nimmoniana: Untapped Potential. Pharmacognosy Reviews, 19(38), 138-143. https://doi.org/10.5530/phrev.20250010

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    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which allows others to share and adapt the work for any purpose, as long as the original authors and source are credited. CC BY 4.0