Periodizing Antioxidant Intake: Why “Recovery” and “Adaptation” Phases Need Different Advice

ABSTRACT

Debate over whether athletes should take antioxidant supplements often proceeds as though a single answer must apply at all times. I write to suggest that the more useful question is not whether, but when—and that antioxidant advice should be periodized to the training phase. According to PubMed, antioxidant supplementation can blunt the redox-sensitive signaling—through pathways such as MAPK and PGC-1α—that drives mitochondrial biogenesis and other adaptations to training, which argues against routine high-dose use during phases where adaptation is the goal. The reactive oxygen species generated by exercise are, in this sense, part of the training stimulus rather than simply a cost. Yet the same compounds may have a legitimate role at other times. According to PubMed, a review of tart cherry juice in athletes found that its polyphenols can lessen pain and accelerate strength recovery while reducing inflammation and oxidative stress, and explicitly noted that such supplementation may not be optimal during the adaptation or build phase but may be beneficial when recovery between intense competitions is the priority. The benefit and the harm depend on the phase.

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• DOI10.5530/phrev.20260005Copy

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© 2026 Author(s)

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